Background herb-drug interactions (hdis) resulting from concomitant use of herbal products with clinical drugs may cause adverse reactions organic anion transporter 1 (oat1) and 3 (oat3) are highly expressed in the kidney and play a key role in the renal elimination of substrate drugs. The human organic anion transporter 4 (hoat4) has been identified as the fourth isoform of oat family hoat4 contributes to move several negatively charged organic compounds between cells and their extracellular milieu. The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs to elucidate the molecular mechanisms for the tubular excretion of diuretics, we have elucidated the interactions of human organic anion transporters (hoats) with diuretics using cells . Read interaction of human organic anion transporter polypeptides 1b1 and 1b3 with antineoplastic compounds, european journal of medicinal chemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
It is a member of the organic anion transporter (oat) family of proteins oat1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles , and the basolateral membrane of proximal tubular cells of the kidneys. Cephalosporin antibiotics are thought to be excreted into the urine via organic anion transporters (oats) the purpose of this study was to elucidate the interaction of human-oats with various cephalosporin antibiotics, using proximal tubule cells stably expressing human-oat1, human-oat3 and human-oat4. Canadian journal of physiology and pharmacology, human organic anion transporter 3 (hoat3) can operate as an exchanger and mediate secretory urate flux cell . 1 organic cation transporters (octs) play an important role in drug safety and efficacy protoberberine alkaloids are ubiquitous organic cations or weak bases with remarkable biological actives this study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine .
The iuphar/bps guide to pharmacology organic anion transporter 4 - organic anion transporters (oats) detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets. In order to elucidate the molecular mechanisms of aa-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hoats) with aas using their stable cell lines aa-i and aa-ii inhibited organic anion uptake by hoat1, hoat3, and hoat4 in dose-dependent manners. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 marcel kaufhold,1 katharina schulz,1 davorka breljak,2 shivangi gupta,1 maja henjakovic,1. Inhibitory interaction potential of 22 antituberculosis drugs on organic anion and cation transporters of the slc22a family the human organic anion transporters .
Interactions of human organic anion transporter 1 (hoat1) with substances associated with forensic toxicology shoetsu chibaa,⇑, toru ikawaa, hiroshi takeshitaa, kazue ichibaa, morihisa sagia, toshiji mukaia,. Organic anion transporters (human: oats rodent: oats) are members of the solute carrier family slc22a, and mediate the transport of a wide range of low molecular weight substrates (nigam et al, 2015). Interaction of cysteine conjugates with human and rabbit organic anion transporter 1 carlotta e groves, lynn muñoz , andrew bahn, gerhard burckhardt, stephen h wright research output : contribution to journal article. In the current study, we characterized the interactions of two uptake transporter proteins, expressed mainly in the liver the organic anion transporter 2 (oat2, encoded by the slc22a7 gene) and the sodium taurocholate cotransporting polypeptide (ntcp, encoded by the slc10a1 gene), stably transfected in human embryonic kidney cells, with some .
Human organic anion transporters hoat1 (slc22a6) and hoat3 (slc22a8) are responsible for renal tubular secretion of an antifolic acid methotrexate, and are considered to be involved in drug interaction of methotrexate with nonsteroidal anti-inflammatory drugs (nsaids). The human organic anion and cation transporters are classified within two slc superfamilies superfamily slco (formerly slc21a ) consists of organic anion transporting polypeptides (oatps), while the organic anion transporters (oats) and the organic cation transporters (octs) are classified in the slc22a superfamily. Antineoplastic compounds are used in the treatment of a variety of cancers the effectiveness of an antineoplastic compound to exert its activity is largely dependent on transport proteins involved in the entry of the compound into the cells, and those which drive it out of the cell organic anion .
Abstract studies of the organic anion transporters (oats) have focused mainly on their interactions with organic anionic substrates however, as suggested when oat1 was originally identified as nkt (lopez-nieto, c e,. An organic-anion-transporting polypeptide (oatp) is a membrane transport protein or 'transporter' that mediates the transport of mainly organic anions across the cell membrane therefore, oatps are present in the lipid bilayer of the cell membrane, acting as the cell's gatekeepers. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 marcel kaufhold katharina schulz.